DRUG INFORMATION RESPONSE CENTER
Selected Submitted Questions (click on each question to retrieve the answer)
Please note that these responses were prepared based on literature available at the time of posting and may not include currently available data
- What is the long-term safety with extremely low LDL levels (<100 mg/dL) in patients treated with PCSK9 inhibitors?
January 10, 2019 - What dose of insulin should be ordered preoperatively?
January 10, 2019 - Is apolipoprotein B a strong indicator of future heart disease in a patient, and what are the typical reference ranges? Above what range is considered high/high risk?
October 16, 2018 - In terms of measuring number of small LDL particles, what are considered very high, high, and normal ranges? Does having a high number of small LDL particles put the patient at further risk for developing heart disease?
October 16, 2018 - What is the prevalence of amputation for the SGLT2 inhibitors?
October 08, 2018 - What are the current outcomes data for PCSK9 inhibitors in the treatment of hyperlipidemia?
June 26, 2018 - Do statins cause dementia?
June 26, 2018 - Does extended release nicotinic acid reduce the risk of hepatotoxicity compared to immediate release nicotinic acid?
June 26, 2018 - Is there a recommended age to discontinue statins (risk vs. benefits) in the geriatric population?
November 22, 2017 - What is the risk of pancreatitis with long-term statin use?
November 22, 2017 - What are the current summary treatment guidelines for the treatment of cancer pain?
November 22, 2017 - What are the range of abstinence rates for varenicline for smoking cessation? Do they differ based on treatment duration? Are there any studies utilizing 3 – 4 months of varenicline treatment?
November 21, 2017 - During a hypertensive urgency do you have any insight into the use of clonidine for acute lowering of blood pressure in the outpatient setting? Is this in any guideline? Are there alternatives?
November 20, 2017 - What is the incidence of seizure risk for patients using Chantix® or Zyban®?
November 20, 2017 - Is there a drug interaction between varenicline (Chantix®) and buprenorphine/naloxone (Suboxone®)?
October 27, 2017 - What is the recommended age to begin monitoring a lipoprotein profile in pediatric patients?
October 27, 2017 - Are there any studies or concerns for long-term use of PrEP with herpes suppressive therapy? Also, are there are any studies on the long-term effects of PrEP?
September 11, 2017 - Why is ophthalmic follow-up required with prolonged use of haloperidol?
September 01, 2017 - What is the evidence either supporting or refuting use of an ACE inhibitor or ARB in a normotensive patient with type 2 diabetes and microalbuminuria? How is microalbuminuria defined and determined?
August 23, 2017 - What is the recommended initial dose of oral Suboxone® in an intravenous heroin drug abuser?
August 08, 2017 - Are there any opioids with a potency somewhere between that of tramadol and hydromorphone that are associated with a lower risk of nausea than tramadol and hydromorphone?
May 26, 2017 - Is a sodium-restricted diet more effective in the African-American population versus other ethnic groups for reducing blood pressure?
May 24, 2017 - Which antihypertensives are more effective in reducing diastolic hypertension versus systolic hypertension?
May 24, 2017 - Can a dose reduction in a pure opioid agonist, such as morphine, result in increased analgesia?
May 24, 2017 - Was there a recent study that concluded that a goal BP of 120/80 should be the target in geriatric patients?
May 24, 2017 - Is there a preference for venlafaxine over duloxetine in terms of treating chronic pain? Is 1 more effective than the other?
May 23, 2017
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