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Selected Submitted Questions (click on each question to retrieve the answer)
Please note that these responses were prepared based on literature available at the time of posting and may not include currently available data
Are there any studies or concerns for long-term use of PrEP with herpes suppressive therapy? Also, are there are any studies on the long-term effects of PrEP? -September 11, 2017
Why is ophthalmic follow-up required with prolonged use of haloperidol? -September 1, 2017
What is the evidence either supporting or refuting use of an ACE inhibitor or ARB in a normotensive patient with type 2 diabetes and microalbuminuria? How is microalbuminuria defined and determined? -August 23, 2017
What is the recommended initial dose of oral Suboxone® in an intravenous heroin drug abuser? -August 8, 2017
Are there any opioids with a potency somewhere between that of tramadol and hydromorphone that are associated with a lower risk of nausea than tramadol and hydromorphone? -May 26, 2017
Is a sodium-restricted diet more effective in the African-American population versus other ethnic groups for reducing blood pressure? -May 24, 2017
Which antihypertensives are more effective in reducing diastolic hypertension versus systolic hypertension? -May 24, 2017
Can a dose reduction in a pure opioid agonist, such as morphine, result in increased analgesia? -May 24, 2017
Was there a recent study that concluded that a goal BP of 120/80 should be the target in geriatric patients? -May 24, 2017
Is there a preference for venlafaxine over duloxetine in terms of treating chronic pain? Is 1 more effective than the other? -May 23, 2017
How can there be a warning regarding concomitant use of varenicline with nicotine replacement therapy yet patients can be on varenicline and smoke concurrently? -April 20, 2017
Are the Nicotrol® inhaler cartridges single use or can they be multi-use if the patient only requires a partial dose? -April 20, 2017
Are there any smoking cessation pharmacotherapy guidelines or studies looking at chewing tobacco or electronic cigarettes? -April 20, 2017
Do the results of the Fagerström Tolerance Scale predict successful abstinence from smoking? -April 20, 2017
Are there data that support concurrent use of gabapentin and a TCA for treatment of chronic non-cancer pain? -November 11, 2016
Are thiazides contraindicated in patients with type 2 diabetes? -November 11, 2016
If someone is taking Suboxone, Subutex or methadone for drug rehab, can they take another controlled substance such as a benzo? I have been told that there is or will be a legislation that states if someone is on Suboxone they cannot be on any other controlled medications. I have also been informed that people that are taking Suboxone cannot take benzodiazepines due to interactions. As for the methadone, I have been told that an internal med/primary care provider cannot prescribe methadone for drug rehab but can prescribe methadone for pain control. -November 11, 2016
Which TCAs and what dosing is recommended for the different types of chronic non-cancer pain as recommended in the chart for key message 1? -November 11, 2016
Are there head to head studies of chlorthalidone versus hydrochlorothiazide? People seem to be mostly using chlorthalidone now? -September 26, 2016
I use 8 wks of high dose (50,000 units) vitamin D for people with levels below 20. Some people are using 12 wks instead. Is there evidence for this? -September 26, 2016
Based on recently published data, are angiotensin-receptor blockers (ARBs) more cardioprotective than angiotensin-converting enzyme inhibitors (ACEIs) for patients with hypertension? And if so, should ARBs be preferred over ACEIs? -September 26, 2016
Should angiotensin-converting enzyme inhibitors (ACE-I) be used for diabetic patients with hypertension only if there is also proteinuria? -September 26, 2016
Why isn’t smoking listed with the lifestyle modifications in the HTN module key message 1? What is the average drop in BP with smoking cessation? -September 26, 2016
What are the current guideline recommendations for the DASH diet? - March 22, 2016
Overview of Novel Oral Anticoagulants Including a Review of Efficacy and Safety in Atrial Fibrillation - March 22, 2016
In a patient who is tolerant to the analgesic effects on one pure opioid agonist, is there any clinical evidence in the literature that switching to a different pure opioid agonist in the short-term and then returning to the original opioid agonist will result in renewed efficacy without the tolerance? - March 1, 2016
Are there any current treatment guidelines or recommendations regarding management of patients who score high on the Opioid Risk Tool and still require opioid treatment?- March 1, 2016
What are the pharmacological properties of Suboxone® that make it an appropriate agent for detoxification? Why not just a mixed agonist-antagonist (i.e., butorphanol, nalbuphine, pentazocine)? What are the advantages/disadvantages of Suboxone® versus methadone? - March 1, 2016
What are the pros and cons of weight loss medications?- January 19, 2016
What is the potential place in therapy of the PCSK9 inhibitors, evolocumab and alirocumab, for hypercholesterolemia?- October 1, 2015
Which statin is associated with the lowest risk of myalgia?- September 29, 2015
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