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Selected Submitted Questions (click on each question to retrieve the answer)
Please note that these responses were prepared based on literature available at the time of posting and may not include currently available data
What is the long-term safety with extremely low LDL levels (<100 mg/dL) in patients treated with PCSK9 inhibitors? -January 10, 2019
What dose of insulin should be ordered preoperatively? -January 10, 2019
Is apolipoprotein B a strong indicator of future heart disease in a patient, and what are the typical reference ranges? Above what range is considered high/high risk? -October 16, 2018
In terms of measuring number of small LDL particles, what are considered very high, high, and normal ranges? Does having a high number of small LDL particles put the patient at further risk for developing heart disease? -October 16, 2018
What is the prevalence of amputation for the SGLT2 inhibitors? -October 8, 2018
What are the current outcomes data for PCSK9 inhibitors in the treatment of hyperlipidemia? -June 26, 2018
Do statins cause dementia? -June 26, 2018
Does extended release nicotinic acid reduce the risk of hepatotoxicity compared to immediate release nicotinic acid? -June 26, 2018
Is there a recommended age to discontinue statins (risk vs. benefits) in the geriatric population? -November 22, 2017
What is the risk of pancreatitis with long-term statin use? -November 22, 2017
What are the current summary treatment guidelines for the treatment of cancer pain? -November 22, 2017
What are the range of abstinence rates for varenicline for smoking cessation? Do they differ based on treatment duration? Are there any studies utilizing 3 - 4 months of varenicline treatment? -November 21, 2017
During a hypertensive urgency do you have any insight into the use of clonidine for acute lowering of blood pressure in the outpatient setting? Is this in any guideline? Are there alternatives? -November 20, 2017
What is the incidence of seizure risk for patients using Chantix® or Zyban®? -November 20, 2017
Is there a drug interaction between varenicline (Chantix®) and buprenorphine/naloxone (Suboxone®)? -October 27, 2017
What is the recommended age to begin monitoring a lipoprotein profile in pediatric patients? -October 27, 2017
Are there any studies or concerns for long-term use of PrEP with herpes suppressive therapy? Also, are there are any studies on the long-term effects of PrEP? -September 11, 2017
Why is ophthalmic follow-up required with prolonged use of haloperidol? -September 1, 2017
What is the evidence either supporting or refuting use of an ACE inhibitor or ARB in a normotensive patient with type 2 diabetes and microalbuminuria? How is microalbuminuria defined and determined? -August 23, 2017
What is the recommended initial dose of oral Suboxone® in an intravenous heroin drug abuser? -August 8, 2017
Are there any opioids with a potency somewhere between that of tramadol and hydromorphone that are associated with a lower risk of nausea than tramadol and hydromorphone? -May 26, 2017
Is a sodium-restricted diet more effective in the African-American population versus other ethnic groups for reducing blood pressure? -May 24, 2017
Which antihypertensives are more effective in reducing diastolic hypertension versus systolic hypertension? -May 24, 2017
Can a dose reduction in a pure opioid agonist, such as morphine, result in increased analgesia? -May 24, 2017
Was there a recent study that concluded that a goal BP of 120/80 should be the target in geriatric patients? -May 24, 2017
Is there a preference for venlafaxine over duloxetine in terms of treating chronic pain? Is 1 more effective than the other? -May 23, 2017
How can there be a warning regarding concomitant use of varenicline with nicotine replacement therapy yet patients can be on varenicline and smoke concurrently? -April 20, 2017
Are the Nicotrol® inhaler cartridges single use or can they be multi-use if the patient only requires a partial dose? -April 20, 2017
Are there any smoking cessation pharmacotherapy guidelines or studies looking at chewing tobacco or electronic cigarettes? -April 20, 2017
Do the results of the Fagerström Tolerance Scale predict successful abstinence from smoking? -April 20, 2017
Are there data that support concurrent use of gabapentin and a TCA for treatment of chronic non-cancer pain? -November 11, 2016
Are thiazides contraindicated in patients with type 2 diabetes? -November 11, 2016
If someone is taking Suboxone, Subutex or methadone for drug rehab, can they take another controlled substance such as a benzo? I have been told that there is or will be a legislation that states if someone is on Suboxone they cannot be on any other controlled medications. I have also been informed that people that are taking Suboxone cannot take benzodiazepines due to interactions. As for the methadone, I have been told that an internal med/primary care provider cannot prescribe methadone for drug rehab but can prescribe methadone for pain control. -November 11, 2016
Which TCAs and what dosing is recommended for the different types of chronic non-cancer pain as recommended in the chart for key message 1? -November 11, 2016
Are there head to head studies of chlorthalidone versus hydrochlorothiazide? People seem to be mostly using chlorthalidone now? -September 26, 2016
I use 8 wks of high dose (50,000 units) vitamin D for people with levels below 20. Some people are using 12 wks instead. Is there evidence for this? -September 26, 2016
Based on recently published data, are angiotensin-receptor blockers (ARBs) more cardioprotective than angiotensin-converting enzyme inhibitors (ACEIs) for patients with hypertension? And if so, should ARBs be preferred over ACEIs? -September 26, 2016
Should angiotensin-converting enzyme inhibitors (ACE-I) be used for diabetic patients with hypertension only if there is also proteinuria? -September 26, 2016
Why isn’t smoking listed with the lifestyle modifications in the HTN module key message 1? What is the average drop in BP with smoking cessation? -September 26, 2016
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